Journal article
Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex
N Matosin, J Arloth, D Czamara, KZ Edmond, M Maitra, AS Fröhlich, S Martinelli, D Kaul, R Bartlett, AR Curry, NC Gassen, K Hafner, NS Müller, K Worf, G Rehawi, C Nagy, T Halldorsdottir, C Cruceanu, M Gagliardi, N Gerstner Show all
Acta Neuropathologica | SPRINGER | Published : 2023
Abstract
Identification and characterisation of novel targets for treatment is a priority in the field of psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a subset of psychiatric patients, with potential to be leveraged as a therapeutic target for these individuals. While it is widely reported that FKBP5/FKBP51 mRNA/protein (FKBP5/1) expression is impacted by psychiatric disease state, risk genotype and age, it is not known in which cell types and sub-anatomical areas of the human brain this occurs. This knowledge is critical to propel FKBP5/1-targeted treatment development. Here, we performed an extensive, large-scale postmortem study (n = 1024) of FKBP5/1, exam..
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Awarded by Cooperative Research Centres, Australian Government Department of Industry
Funding Acknowledgements
Open Access funding enabled and organized by Projekt DEAL. Dr Matosin was supported by a Project Grant (#PG2020645) and Al & Val Rosenstrauss Fellowship from the Rebecca L. Cooper Medical Research Foundation, as well as an Australian National Health and Medical Research Council (NHMRC) Early Career Fellowship (APP1105445), Alexander von Humboldt Foundation Research Fellow-ship and International Brain Research Organisation (IBRO) Research Fellowship. Dr Matosin (#26486), Dr Arloth (#28063) and Dr Gassen (#25348) were all supported with NARSAD Young Investigator Grants. Dr Mechawar and Dr Turecki were supported by grants from The Canadian Institutes of Health Research, Healthy Brains, Healthy Lives McGill grant scheme and ERA-NET NEURON (Network of European Funding for Neuroscience Research). This work was supported by the Hope for Depression Research Foundation.